Qualitätsorientierte Integration technischer, pädagogisch-didaktischer und ökonomischer Systemkomponenten zur nachhaltigen Implementierung technologiegestützter Bildungsservices

Bisherige Forschungsansätze der Bereiche Qualität, Technologie, Pädagogik-Didaktik und Ökonomie führten trotz des Einsatzes umfangreicher finanzieller Mittel und personeller Ressourcen zu keiner nachhaltigen Implementierung von E-Learning. Die vorliegende wissenschaftliche Arbeit verfolgt einen Ansatz, bei dem sie von konkreten Anforderungen an marktfähige Bildungsservices ausgehend, die Lösung zu einer nachhaltigen Implementierung erarbeitet. Dabei positioniert sie die qualitativen Ansprüche eines Lerners und ökonomische Erfordernisse als zentrale Anforderungsinstanzen. Der eingeschlagene Lösungsweg setzt auf einen neuen integrierenden Ansatz, bei dem die Qualität als Integrationsebene für technische, pädagogisch-didaktische und ökonomische Systemkomponenten dient. Diesem entwickelten Qualitätsansatz folgt eine Transformation in ein auf die Bedürfnisse der beruflichen Aus- und Weiterbildung adaptiertes Geschäftsmodell. Sie beschreibt eine vollständige Prozesskette zur Generierung und zum Angebot technologiegestützter Bildungsservices. Ein angepasstes Partnerkonzept und die Umsetzung des Modells in Organisationseinheiten runden die konzeptionellen Modellbetrachtungen ab. Ein an realen Marktbedingungen orientierter Geschäftsplan verdeutlicht das Potenzial des gewählten Ansatzes bezüglich einer deutlichen Kostenreduktion und gleichzeitiger Verbesserung der Lernqualität. Abschließend liefert diese Arbeit einen Einblick in die Grundlagen zum Calculation Object Model (COM), welches das traditionell sehr verbreitete ABC-Kostenverfahren deutlich vereinfacht und beim Einsatz in Bildungsszenarien zur ROI-Bestimmung signifikante Vorteile besitzt.Previous research approaches of the areas of quality, technology, education didactics and economy did not lead to any lasting implementation of E-Learning. The scientific work of Helmut W. Jung describes an innovative approach which starts from concrete requirements on marketable educational services. It places the qualitative claims of a learner and economic requirements as the central request authorities. The developped solution is a new integrating approach at which the quality serves as an integration instrument for technical, didactical and economical system components. A transformation into a business model oriented at the needs of the professional education and further education follows the developed quality model. It describes a complete E-Learning process chain, an adapted partner concept and the translation of the model into organisation units. A business plan - orientated at real market conditions - clarifies the potential of the chosen approach regarding cost reduction and simultaneous improvement of the teaching and learning quality. At last the work delivers an insight into the bases for the Calculation Object Model (COM) which one simplifies the traditionally very common ABC costing. COM delievers significant ROI advantages into education scenarios

Association of Hepatitis C Virus—Specific CD8+ T Cells with Viral Clearance in Acute Hepatitis C

CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the outcome of infection. Eighteen patients with acute hepatitis C and 19 normal donors were studied. Hepatitis C virus (HCV)—specific CD8+ T cells were identified in the enzyme-linked immunospot assay by their interferon-γ (IFN-γ) production after specific stimulation. The highest numbers of IFN-γ—producing HCV-specific CD8+ T cells were found in patients with acute hepatitis C and a self-limited course of disease during the first 6 months after onset of disease, but these numbers dropped thereafter to undetectable levels. The differences in responsiveness between patients with self-limited disease versus patients with a chronic course were statistically significant (P < .001). Our data show that the number of IFN—γ-producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infectio

Association of Hepatitis C Virus—Specific CD8+ T Cells with Viral Clearance in Acute Hepatitis C

CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the outcome of infection. Eighteen patients with acute hepatitis C and 19 normal donors were studied. Hepatitis C virus (HCV)—specific CD8+ T cells were identified in the enzyme-linked immunospot assay by their interferon-γ (IFN-γ) production after specific stimulation. The highest numbers of IFN-γ—producing HCV-specific CD8+ T cells were found in patients with acute hepatitis C and a self-limited course of disease during the first 6 months after onset of disease, but these numbers dropped thereafter to undetectable levels. The differences in responsiveness between patients with self-limited disease versus patients with a chronic course were statistically significant (P < .001). Our data show that the number of IFN—γ-producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infection

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good